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MIF has emerged not long ago as a very important effector molecule on the innate immune process. Unlike most cytokines, MIF is expressed constitutively by immune and endocrine cells, as well as with the epithelial lining of tissues in immediate contact with the exterior setting, indicating a job for MIF for a regulator of host responses to infectio

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A recent discovery highlighted a novel job for intracellular MIF in regulating the accumulation of misfolded Cu/Zn superoxide dismutase (SOD1). Mutations in SOD1 are linked to twenty% of the instances of familial amyotrophic lateral sclerosis, that is characterized by lack of motor neurons [72]. DDTL has somewhere around 70% sequence identificatio

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